From Rome
1) Take A1 motorway towards Florence until Chiusi-Chianciano exit. Then follow directions for Montepulciano, Pienza until arriving in Rocca d’Orcia
2) Take Cassia Route (Via Francigena) towards Viterbo, then follow directions for Monte Amiata and Montalcino until arriving in Rocca d’Orcia

From Florence
Take the Firenze-Siena freeway, then follow Cassia Rooute towards Rome until arriving in Rocca d’Orcia

From Grosseto
Take Siena freeway until Paganico. Then follow directions for Monte Amiata and Montalcino until arriving in Rocca d’Orcia